Does Blood of Healthy Subjects Contain Bacterial Ribosomal DNA?

Author:

Nikkari Simo12,McLaughlin Ian J.3,Bi Wanli3,Dodge Deborah E.3,Relman David A.12

Affiliation:

1. Department of Microbiology and Immunology and Department of Medicine, Stanford University School of Medicine, Stanford, California 943051;

2. Veterans Affairs Palo Alto Health Care System, Palo Alto, California 943042; and

3. Applied Biosystems, Foster City, California 944043

Abstract

ABSTRACT Real-time PCR methods with primers and a probe targeting conserved regions of the bacterial 16S ribosomal DNA (rDNA) revealed a larger amount of rDNA in blood specimens from healthy individuals than in matched reagent controls. However, the origins and identities of these blood-associated bacterial rDNA sequences remain obscure.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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