Affiliation:
1. Institut für Virologie, Freie Universität Berlin, Berlin, Federal Republic of Germany.
Abstract
The etiological agent of Borna disease, a persistent virus infection of the central nervous system with differently expressed symptomatology, was morphologically unknown. Here we provide the first convincing data on its phenotypic architecture. Salt-released virus comprising the biological parameters of Koch's postulates has an unsegmented single-stranded RNA. A dense band (1.22 g/cm3) in CsCl contains 90-nm particles which appear to be enveloped and a fraction of 50- to 60-nm particles. Labeling of the virions with neutralizing antisera and colloidal gold conjugates indicates that the 90-nm particles most likely represent the causative agent.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference30 articles.
1. Electron microscopic studies of rabbit central and peripheral nervous system in experimental Borna disease;Anzil A. P.;Acta Neuropathol.,1972
2. Mikroskopische und ultrastrukturelle Untersuchungen an Joest-Degen'schen Einschlupkorperchen bei spontaner Borna Krankheit des Pferdes;Bestetti G.;Schweiz. Arch. Tierheilkd.,1976
3. A novel marker for Borna disease virus infection;Bode L;Lancet,1994
4. Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells;Briese T.;Proc. Natl. Acad. Sci. USA,1992
5. Genomic organization of Borna disease virus;Briese T.;Proc. Natl. Acad. Sci. USA,1994
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献