<i>In vitro</i> activity of taurolidine against clinical <i>Candida auris</i> isolates: relevance to catheter-related bloodstream infections-Reference-Cited by-同舟云学术

In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections

Published:2024-07-09 Issue:7 Volume:68 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Reidenberg Bruce E.¹,Jenkins Stephen G.²³,Crandon Jared L.⁴,Hurlburt Elizabeth⁴,Tan Xing⁴,Rhomberg Paul R.⁵,Arends S. J. Ryan⁵,Pfaffle Antony⁴^ORCID

Affiliation:

1. Department of Pharmacology, Weill Cornell Medicine, New York, New York, USA

2. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA

3. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

4. CorMedix Inc., Berkeley Heights, New Jersey, USA

5. Element Iowa City (JMI Laboratories), North Liberty, Iowa, USA

Abstract

ABSTRACT Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C . auris isolates. Taurolidine was highly active with a MIC 50 /MIC 90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00381-24

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