Gentian Violet Exhibits Activity against Biofilms Formed by Oral Candida Isolates Obtained from HIV-Infected Patients

Abstract

ABSTRACTThe effect of gentian violet againstCandida albicansand non-Candida albicansbiofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibitCandida albicansgermination was also assessed. Gentian violet activity againstCandidabiofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibitedCandidagermination in a concentration-dependent manner.