Association betweenpncAGene Mutations, Pyrazinamidase Activity, and Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Association betweenpncAGene Mutations, Pyrazinamidase Activity, and Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis

Published:2014-05-27 Issue:8 Volume:58 Page:4928-4930
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Aono Akio,Chikamatsu Kinuyo,Yamada Hiroyuki,Kato Tomoko,Mitarai Satoshi

Abstract

ABSTRACTWe determined MICs for, confirmed the presence ofpncAmutations in, and performed pyrazinamidase testing on colonies (subclones) obtained from seven isolates that exhibited differential pyrazinamide (PZA) susceptibility. Six of the seven strains were found to exhibit characteristics resulting from the mixture of strains possessing different properties. In addition, our analysis revealed largepncA-spanning deletions (1,565 bp, 4,475 bp, and 6,258 bp) in three strains that showed high PZA resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference17 articles.

1. Controlled clinical trial of 4 short-course regimens of chemotherapy (three 6-month and one 8-month) for pulmonary tuberculosis: final report. East and Central African/British Medical Research Council Fifth Collaborative Study;British Medical Research Council;Tubercle,1986

2. Pyrazinamide sterilizing activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations;Heifets;Am. Rev. Respir. Dis.,1992

3. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus;Scorpio;Nat. Med.,1996

4. Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide;Zhang;J. Med. Microbiol.,2002

5. Activation of pyrazinamide and nicotinamide in acidic environments in vitro;McDermott;Am. Rev. Tuberc.,1954

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