Author:
Livorsi D. J.,Crispell E.,Satola S. W.,Burd E. M.,Jerris R.,Wang Y. F.,Farley M. M.
Abstract
ABSTRACTWe sought to define the prevalence ofblaZgene types and the inoculum effect to cefazolin among methicillin-susceptibleStaphylococcus aureus(MSSA) bloodstream infections. TheblaZgene was present in 142/185 (77%) isolates. A total of 50 (27%) isolates had a ≥4-fold increase in the cefazolin MIC from a standard to a high inoculum, and 8 (4%) demonstrated a nonsusceptible cefazolin MIC, all type AblaZstrains. The efficacy of cefazolin in the presence of the inoculum effect requires further study.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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