Mucosal Gene Expression in Response to SARS-CoV-2 Is Associated with Viral Load-Reference-Cited by-同舟云学术

Mucosal Gene Expression in Response to SARS-CoV-2 Is Associated with Viral Load

Published:2023-02-28 Issue:2 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rajagopala Seesandra V.¹,Strickland Britton A.¹²,Pakala Suman B.¹,Kimura Kyle S.³,Shilts Meghan H.¹,Rosas-Salazar Christian⁴,Brown Hunter M.¹,Freeman Michael H.³,Wessinger Bronson C.⁴,Gupta Veerain⁴,Phillips Elizabeth¹,Mallal Simon A.¹⁵,Turner Justin H.²,Das Suman R.¹²³^ORCID

Affiliation:

1. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

4. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

5. Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia

Abstract

Several prior studies have shown that SARS-CoV-2 viral load can predict the likelihood of disease spread and severity. A higher detectable SARS-CoV-2 plasma viral load was associated with worse respiratory disease severity.

Funder

HHS | Centers for Disease Control and Prevention

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01478-22

Reference56 articles.

1. [Comment] The COVID‑19 pandemic as a scientific and social challenge in the 21st century