Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance-Reference-Cited by-同舟云学术

Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance

Published:2016-01 Issue:1 Volume:54 Page:185-189
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Kirwan Daniela E.¹²,Ugarte-Gil Cesar²³,Gilman Robert H.⁴⁵,Caviedes Luz⁵,Rizvi Hasan⁶,Ticona Eduardo⁷⁸⁹,Chavez Gonzalo⁷,Cabrera José Luis¹⁰,Matos Eduardo D.⁸¹¹,Evans Carlton A.¹²¹³,Moore David A. J.⁵¹⁴,Friedland Jon S.²

Affiliation:

1. Department of Medical Microbiology, St. George's Hospital, London, United Kingdom

2. Infectious Diseases and Immunity, Imperial College London, London, United Kingdom

3. Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

4. Department of International Health, Johns Hopkins University, Baltimore, Maryland, USA

5. Laboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru

6. Department of Cellular Pathology, Barts Health NHS Trust, London, United Kingdom

7. Infectious Diseases and Tropical Medicine Unit, Hospital Nacional Dos de Mayo, Lima, Peru

8. Universidad Nacional Mayor de San Marcos, Lima, Peru

9. Universidad de San Martin de Porres, Lima, Peru

10. Department of Pulmonology, Hospital Daniel Alcides Carrión, Callao, Peru

11. Infectious Diseases Unit, Hospital Nacional Arzobispo Loayza, Lima, Peru

12. Infectious Diseases and Immunity, and Wellcome Trust Centre for Global Health Research, Imperial College London, London, United Kingdom

13. IFHAD: Innovation for Health and Development, Universidad Peruana Cayetano Heredia, Lima, Peru

14. TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom

Abstract

ABSTRACT In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02227-15

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