Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8 + IFN-γ + Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation-Reference-Cited by-同舟云学术

Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8 + IFN-γ + Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation

Published:2021-09-09 Issue:19 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Matundan Harry H.¹^ORCID,Wang Shaohui¹,Jaggi Ujjaldeep¹^ORCID,Yu Jack¹,Ghiasi Homayon¹^ORCID

Affiliation:

1. Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, CSMC-SSB3, Los Angeles, California, USA

Abstract

Direct binding of HSV-1 ICP22 to the CD80 promoter downregulates the expression of the costimulatory molecule CD80 but not CD86. In this study, we fine mapped the region of ICP22 required for binding to the CD80 promoter and constructed a recombinant virus containing a deletion in ICP22 that failed to bind to the CD80 promoter.

Funder

HHS | NIH | National Eye Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01036-21

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