Emergence of Two AcrB Substitutions Conferring Multidrug Resistance to Salmonella spp.-Reference-Cited by-同舟云学术

Emergence of Two AcrB Substitutions Conferring Multidrug Resistance to Salmonella spp.

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yang Ling¹²,Shi Haiyang¹,Zhang Lijuan¹,Lin Xiaoling¹,Wei Yinan²,Jiang Hongxia¹³,Zeng Zhenling¹³

Affiliation:

1. Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

2. Department of Chemistry, University of Kentucky, Lexington, Kentucky, USA

3. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China

Abstract

AcrAB-TolC is a major tripartite multidrug efflux pump conferring resistance to a wide variety of compounds in Gram-negative pathogens. Many AcrB mutants have been constructed through site-directed mutagenesis to probe the mechanism of AcrB function in antibiotic resistance.

Funder

Bureau of Science and Information Technology of Guangzhou Municipality | Guangzhou Science and Technology Program key projects

Center for Hierarchical Manufacturing, National Science Foundation

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01589-20

Reference37 articles.