Affiliation:
1. Infectious Disease Division, Department of Internal Medicine, University of Cincinnati College of Medicine and the Cincinnati General Hospital, Cincinnati, Ohio 45229
Abstract
A method of induction of L colonies of
Staphylococcus aureus
by cycloserine, the propagation of wall-defective staphylococci (WDS), and the development and antimicrobial susceptibility of stable WDS are presented. The growth and morphology of the cycloserine-induced L colonies and WDS were indistinguishable from those induced by methicillin or lysostaphin. The antimicrobial susceptibility of the stable cycloserine-induced WDS was similar to that of the stable methicillin-induced and lysostaphin-induced WDS by both broth dilution and agar diffusion techniques. A survey of the English literature reveals that wall-defective bacteria are always resistent to antimicrobial agents which inhibit cell wall synthesis (cycloserine, penicillins, and cephalosporins). They are virtually all susceptible to antimicrobial agents which have other modes of action. The susceptibility to vancomycin and bacitracin varied from study to study.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
12 articles.
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