Prospective randomized trial of efficacy of ganciclovir versus that of anti-cytomegalovirus (CMV) immunoglobulin to prevent CMV disease in CMV-seropositive heart transplant recipients treated with OKT3

Author:

Aguado J M1,Gomez-Sanchez M A1,Lumbreras C1,Delgado J1,Lizasoain M1,Otero J R1,Rufilanchas J J1,Noriega A R1

Affiliation:

1. Department of Microbiology, Hospital Doce de Octubre, Madrid, Spain.

Abstract

We compared the efficacy of ganciclovir versus that of cytomegalovirus (CMV) immunoglobulin for the prevention of CMV disease in 31 CMV-seropositive heart transplant recipients who had received early immunoprophylaxis with OKT3 monoclonal antibodies. The incidence of CMV disease and visceral involvement was much higher in the CMV immunoglobulin group than in the ganciclovir group (40 versus 6%, respectively; P = 0.03). No adverse effects were found in the CMV immunoglobulin group, but 19% of the patients in the ganciclovir group developed mild leukopenia or a mild increase in their serum creatinine levels.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

1. Aguado J. M. C. Lumbreras M. Gomez M. Lizasoain A. Fuertes J. Otero and A. R. Noriega. 1992. A randomized controlled trial of ganciclovir (GCV) vs. cytomegalovirus (CMV) immunoglobulin (CMVIG) to prevent CMV disease in cardiac transplant (CT) recipients treated with OKT3 abstr. 1107 p. 295. In Program and abstracts of the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology Washington D.C.

2. Passive immunization against cytomegalovirus in allograft recipients. The Rotterdam Heart Transplant Program experience;Balk A. H.;Infection,1993

3. Prevention of cytomegalovirus disease in heart transplant recipients by prophylaxis with cytomegalovirus hyper immune globulin plus oral acyclovir;Eisenmann D.;Transplant. Proc.,1990

4. Use of immune globulin to prevent symptomatic cytomegalovirus disease in transplant recipients-a meta-analysis;Glowacki L. S.;Clin. Transplant.,1994

5. Cytomegalovirus hyperimmunoglobulin prophylaxis in the prevention of cytomegalovirus infection in immunosuppressed heart transplant patients;Havel M.;Transplant. Proc.,1990

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