Activities of ABT-773 against Listeria monocytogenes and Coryneform Bacteria of Clinical Interest

Author:

Conejo María del Carmen1,Martínez-Martínez Luis12,Pascual Álvaro12,Suárez Ana Isabel2,Perea Evelio J.12

Affiliation:

1. Department of Microbiology, School of Medicine

2. University Hospital Virgen Macarena, University of Seville, Seville, Spain

Abstract

ABSTRACT The in vitro activities of ABT-773 were evaluated against 15 Listeria monocytogenes strains and 196 coryneform bacteria isolated from clinical samples. One hundred percent of the L. monocytogenes strains were inhibited by ≤0.015 μg of ABT-773/ml. MICs of ABT-773 (μg/ml) at which 50% of the isolates tested were inhibited (MIC 50 s) and MIC 90 s for other organisms were 0.125 and 0.5 ( Corynebacterium amycolatum ), 1 and >32 ( Corynebacterium jeikeium ), 0.03 and >32 ( Corynebacterium minutissimum ), >32 and >32 ( Corynebacterium pseudodiphtheriticum and Corynebacterium urealyticum ), 0.125 and >32 ( Corynebacterium striatum ), and 0.03 and 0.5 ( Rhodococcus equi ), respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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