A Novel Campylobacter jejuni Two-Component Regulatory System Important for Temperature-Dependent Growth and Colonization-Reference-Cited by-同舟云学术

A Novel Campylobacter jejuni Two-Component Regulatory System Important for Temperature-Dependent Growth and Colonization

Published:1999-05-15 Issue:10 Volume:181 Page:3298-3302
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Brás Ana M.¹,Chatterjee Shimonti¹,Wren Brendan W.²,Newell Diane G.³,Ketley Julian M.¹

Affiliation:

1. Department of Genetics, University of Leicester, Leicester,1

2. Department of Medical Microbiology, St. Bartholomew’s and the Royal London School of Medicine and Dentistry, London,2and

3. Applied and Molecular Immunology Unit, Central Veterinary Laboratory, New Haw, Addlestone, Surrey,3 United Kingdom

Abstract

ABSTRACT Campylobacter jejuni colonizes the intestines of domestic and wild animals and is a common cause of human diarrheal disease. We identified a two-component regulatory system, designated the RacR-RacS (reduced ability to colonize) system, that is involved in a temperature-dependent signalling pathway. A mutation of the response regulator gene racR reduced the organism’s ability to colonize the chicken intestinal tract and resulted in temperature-dependent changes in its protein profile and growth characteristics.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.181.10.3298-3302.1999

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