Echinocandins for the Treatment of Invasive Aspergillosis: from Laboratory to Bedside

Author:

Aruanno Marion12,Glampedakis Emmanouil1,Lamoth Frédéric12

Affiliation:

1. Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

2. Institute of Microbiology, Department of Laboratories, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

Abstract

Echinocandins (caspofungin, micafungin, anidulafungin), targeting β-1,3-glucan synthesis of the cell wall, represent one of the three currently available antifungal drug classes for the treatment of invasive fungal infections. Despite their limited antifungal activity against Aspergillus spp., echinocandins are considered an alternative option for the treatment of invasive aspergillosis (IA).

Funder

Swiss National Science Foundation

Fondation Santos-Suarez pour la Recherche Médicale

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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