Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats-Reference-Cited by-同舟云学术

Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats

Published:2008-09 Issue:9 Volume:52 Page:3454-3456
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abe Fumie¹,Ueyama Jun²,Kawasumi Noriyo¹,Nadai Masayuki³,Hayashi Tamon¹,Kato Miki¹,Ohnishi Masafumi¹,Saito Hiroko¹,Takeyama Naoshi⁴,Hasegawa Takaaki¹

Affiliation:

1. Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine, Nagakute-cho, Aichi-gun, Aichi 480-1195

2. Department of Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daikominami, Higashi-ku, Nagoya 461-8672

3. Faculty of Pharmaceutical Sciences, Meijo University, 150 Yagotoyama, Tenpaku-ku, Nagoya 468-8503

4. Department of Critical Care Medicine, Aichi Medical University School of Medicine, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan

Abstract

ABSTRACT There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00396-08

Reference20 articles.

1. Life Sci.

2. Bae, S. K., H. E. Kang, M. K. Kang, J. W. Kim, T. Kim, and M. G. Lee. 2006. Pharmacokinetics of oltipraz in mutant Nagase analbuminemic rats. J. Pharm. Sci.95:998-1005.

3. Choi, Y. H., S. K. Bae, S. O. Kim, and M. G. Lee. 2007. Pharmacokinetics of 5-fluorouracil in mutant Nagase analbuminemic rats: faster metabolism of 5-fluorouracil via CYP1A. Biopharm. Drug Dispos.28:87-95.

4. Hebert, M. F., D. K. Blough, R. W. Townsend, M. Allison, D. Buell, J. Keims, and I. Bekersky. 2005. Concomitant tacrolimus and micafungin pharmacokinetics in healthy volunteers. J. Clin. Pharmacol.45:1018-1024.

5. Hebert, M. F., R. W. Townsend, S. Austin, G. Balan, D. K. Blough, D. Buell, J. Keims, and I. Bekersky. 2005. Concomitant cyclosporine and micafungin pharmacokinetics in healthy volunteers. J. Clin. Pharmacol.45:954-960.

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