In vitro activity of Ro 23-9424 against clinical isolates of Legionella species-Reference-Cited by-同舟云学术

In vitro activity of Ro 23-9424 against clinical isolates of Legionella species

Published:1992-11 Issue:11 Volume:36 Page:2559-2561
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Edelstein P H¹,Edelstein M A¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.

Abstract

Agar and broth microdilution MICs of Ro 23-9424 that inhibited 90% of 22 Legionella clinical isolates tested were 0.64 and 0.08 micrograms/ml, respectively; respective erythromycin values were 1.0 and 0.12 micrograms/ml. Ro 23-9424 (1 microgram/ml) was slightly more active than the same erythromycin concentration in a macrophage system, for both Legionella pneumophila strains studied.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.36.11.2559

Reference14 articles.

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