Affiliation:
1. Fachbereich Gentechnik und Genetik, Robert Koch-Institut, Berlin, Germany.
Abstract
The origin of DNA replication of porcine circovirus (PCV) was mapped to a 111-bp fragment. On top of a hairpin, a nonanucleotide (TAGTATTAC) homologous to nonanucleotides of other viruses was identified. Mutation of this element abolishes replication. PCV may be related to a virus family characterized by single-stranded circular DNA genomes, rolling-circle replication, and homology of their rep proteins.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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