Molecular Basis for Resistance of Acanthamoeba Tubulins to All Major Classes of Antitubulin Compounds-Reference-Cited by-同舟云学术

Molecular Basis for Resistance of Acanthamoeba Tubulins to All Major Classes of Antitubulin Compounds

Published:2008-03 Issue:3 Volume:52 Page:1133-1135
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Henriquez Fiona L.¹,Ingram Paul R.¹,Muench Stephen P.²,Rice David W.²,Roberts Craig W.¹

Affiliation:

1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, United Kingdom

2. Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom

Abstract

ABSTRACT Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00355-07

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