Molecular Confirmation that Fasciola gigantica Can Undertake Aberrant Migrations in Human Hosts

Author:

Le Thanh Hoa1,De Nguyen Van2,Agatsuma Takeshi3,Blair David4,Vercruysse Jozef5,Dorny Pierre5,Nguyen Thanh Giang Thi1,McManus Donald P.6

Affiliation:

1. Department of Immunology, Institute of Biotechnology, Hanoi, Vietnam

2. Faculty of Parasitology, Institute of Malariology, Parasitology and Entomology, Hanoi, Vietnam

3. Department of Environmental Health Sciences, Kochi Medical School, Kochi, Japan

4. School of Tropical Biology, James Cook University, Townsville, QLD 4811, Australia

5. Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium

6. Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia

Abstract

ABSTRACT Two cases of aberrant migration by the liver fluke Fasciola gigantica in humans are reported. In both cases, subadult worms emerged through the skin. The identity of the worms was confirmed from their DNA sequences. This uncommon human pathogen might be more likely than F. hepatica to undertake aberrant migrations in humans.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference21 articles.

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2. Ashrafi, K., J. Massoud, K. Holakouei, M. Mahmoodi, M. A. Joafshani, M. A. Valero, M. V. Fuentes, M. Khoubbane, P. Artigas, M. D. Bargues, and S. Mas-Coma. 2004. Evidence suggesting that Fasciola gigantica may be the most prevalent causal agent of fascioliasis in northern Iran. Iranian J. Public Health33:31-37.

3. Chang, Z. S., B. Wu, D. Blair, Y. Zhang, L. Hu, S. H. Chen, M. Chen, Z. Feng, and G. Davis. 2000. Gene sequences for identification of Paragonimus eggs from a human case. Chin. J. Parasitol. Parasite Dis.18:213-215.

4. Dalimi, A., R. Hadighi, and R. Madani. 2004. Partially purified fraction (PPF) antigen from adult Fasciola gigantica for the serodiagnosis of human fascioliasis using dot-ELISA technique. Ann. Saudi Med.24:18-20.

5. De, N. V., K. D. Murrell, L. D. Cong, P. D. Cam, L. V. Chau, N. D. Toan, and A. Dalsgaard. 2003. The food-borne trematode zoonoses of Vietnam. Southeast Asian J. Trop. Med. Public Health34(Suppl. 1):12-34.

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