1. Department of Medicine and Cardiovascular Research Center 1 and
2. Department of Pharmacology and Toxicology, 2 Medical College of Wisconsin, Milwaukee, Wisconsin 53226;
3. Department of Surgery, The Queen's University of Belfast, Institute of Clinical Science, The Royal Group of Hospitals, Belfast, Northern Ireland, United Kingdom 3 ; and
4. Department of Internal Medicine, University of Florence, Florence 50134, Italy4