Distinct Leishmania braziliensis Isolates Induce Different Paces of Chemokine Expression Patterns

Author:

Teixeira Maria Jania123,Fernandes Juliana Dumet12,Teixeira Clarissa Romero12,Andrade Bruno Bezerril12,Pompeu Margarida Lima3,Santana da Silva João4,Brodskyn Cláudia Ida125,Barral-Netto Manoel125,Barral Aldina125

Affiliation:

1. Centro de Pesquisas Gonçalo Moniz-Fiocruz

2. Faculdade de Medicina, Universidade Federal da Bahia-UFBA

3. Núcleo de Medicina Tropical, Universidade Federal do Ceará-UFC, Fortaleza

4. Departamento de Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Brazil

5. Immunology Investigation Institute, Salvador

Abstract

ABSTRACT Inflammatory events during Leishmania braziliensis infection in mice were investigated. Large lesions were directly correlated with the inflammatory reaction but not with parasite burden. Different L. braziliensis strains induce different paces of chemokine expression patterns, leading to diverse cell recruitment and differential inflammatory responses.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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