Long Noncoding RNA MIR2187HG Suppresses TBK1-Mediated Antiviral Signaling by Deriving miR-2187-3p in Teleost Fish-Reference-Cited by-同舟云学术

Long Noncoding RNA MIR2187HG Suppresses TBK1-Mediated Antiviral Signaling by Deriving miR-2187-3p in Teleost Fish

Published:2022-01-12 Issue:1 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chang Renjie¹,Zheng Weiwei¹,Sun Yuena¹²³,Geng Shang¹,Xu Tianjun¹⁴²³^ORCID

Affiliation:

1. Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China

2. Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (grid.412514.7Shanghai Ocean University), Ministry of Education, Shanghai, China

3. National Pathogen Collection Center for Aquatic Animals, Shanghai Ocean University, Shanghai, China

4. Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China

Abstract

SCRV infection upregulates MIR2187HG levels, which in turn suppresses SCRV-triggered type I interferon production, thus promoting viral replication in miiuy croaker. Notably, MIR2187HG regulates the release of miR-2187-3p, and TBK1 is a target of miR-2187-3p.

Funder

National Key Research and Development Project

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01484-21

Reference59 articles.

1. Ligand specificities of Toll-like receptors in fish: Indications from infection studies

2. Teleost TLR22 Recognizes RNA Duplex to Induce IFN and Protect Cells from Birnaviruses