Activity of ETX0462 toward Some <i>Burkholderia</i> spp.-Reference-Cited by-同舟云学术

Activity of ETX0462 toward Some Burkholderia spp.

Published:2023-01-24 Issue:1 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zeiser Elise T.¹,Becka Scott A.¹,LiPuma John J.²^ORCID,Papp-Wallace Krisztina M.¹³⁴^ORCID

Affiliation:

1. Research Service, VA Northeast Healthcare System, Cleveland, Ohio, USA

2. Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA

3. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

4. Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Burkholderia cepacia complex (Bcc) and Burkholderia gladioli are opportunistic human pathogens that are inherently multidrug resistant, limiting treatment options for infections. Here, a novel diazabicyclooctane, ETX0462, was evaluated for activity against Bcc and B . gladioli .

Funder

Entasis Therapeutics

Cystic Fibrosis Foundation

United States Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01352-22

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