Azithromycin Inhibits Quorum Sensing in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Azithromycin Inhibits Quorum Sensing in Pseudomonas aeruginosa

Published:2001-06 Issue:6 Volume:45 Page:1930-1933
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tateda Kazuhiro¹,Comte Rachel²,Pechere Jean-Claude²,Köhler Thilo²,Yamaguchi Keizo¹,Van Delden Christian²

Affiliation:

1. Department of Microbiology, Toho University School of Medicine, Tokyo, Japan,1 and

2. Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2

Abstract

ABSTRACT We report that 2 μg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI . We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.6.1930-1933.2001

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