Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression-Reference-Cited by-同舟云学术

Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression

Published:2018-10 Issue:19 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Shen Yong¹,Bassett MacLean A.¹,Gurumurthy Aishwarya¹,Nar Rukiye¹,Knudson Isaac J.¹,Guy Cameron R.¹,Perez Alex¹,Mellen Russell W.¹,Ikeda Masatoshi²,Hossain Mir A.¹,Huang Suming¹,Igarashi Kazuhiko²,Bungert Jörg¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, College of Medicine, Health Cancer Center, Genetics Institute, Center for Epigenetics, University of Florida, Gainesville, Florida, USA

2. Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

Abstract

The organization of the five β-type globin genes on chromosome 11 reflects the timing of expression during erythroid cell development, with the embryonic ε-globin gene being located at the 5′ end, followed by the two fetal γ-globin genes, and with the adult β- and δ-globin genes being located at the 3′ end. Here, we functionally characterized a DNase I-hypersensitive site (HS) located 4 kb upstream of the Gγ-globin gene (HBG-4kb HS).

Funder

NIH

American Heart Association

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00197-18

Reference56 articles.

1. Functional and Mechanistic Diversity of Distal Transcription Enhancers

2. The Chromatin Fingerprint of Gene Enhancer Elements