PorZ, an Essential Component of the Type IX Secretion System of Porphyromonas gingivalis , Delivers Anionic Lipopolysaccharide to the PorU Sortase for Transpeptidase Processing of T9SS Cargo Proteins

Author:

Madej Mariusz1ORCID,Nowakowska Zuzanna1,Ksiazek Miroslaw12,Lasica Anna M.32,Mizgalska Danuta1,Nowak Magdalena1,Jacula Anna1,Bzowska Monika4,Scavenius Carsten5,Enghild Jan J.5,Aduse-Opoku Joseph6,Curtis Michael A.6,Gomis-Rüth F. Xavier7,Potempa Jan12ORCID

Affiliation:

1. Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland

2. Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky, USA

3. Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland

4. Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland

5. Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, Aarhus University, Åarhus, Denmark

6. Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom

7. Proteolysis Lab, Department of Structural Biology, Molecular Biology Institute of Barcelona, Higher Scientific Research Council (CSIC), Barcelona, Catalonia, Spain

Abstract

Bacteria have evolved multiple systems to transport effector proteins to their surface or into the surrounding milieu. These proteins have a wide range of functions, including attachment, motility, nutrient acquisition, and toxicity in the host. Porphyromonas gingivalis , the human pathogen responsible for severe gum diseases (periodontitis), uses a recently characterized type IX secretion system (T9SS) to translocate and anchor secreted virulence effectors to the cell surface.

Funder

Polish Ministry of Science and Higher Education

HHS | NIH | National Institute of Dental and Craniofacial Research

National Science Center, Poland

Spanish Ministry of Science and Innovation

National Government of Catalonia

Foundation “La Marato de TV3”, Catalonia

Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Cited by 20 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3