Plasmodium falciparum Genetic Diversity in Coincident Human and Mosquito Hosts-Reference-Cited by-同舟云学术

Plasmodium falciparum Genetic Diversity in Coincident Human and Mosquito Hosts

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lapp Zena¹^ORCID,Obala Andrew A.²,Abel Lucy³,Rasmussen David A.⁴⁵,Sumner Kelsey M.⁶⁷,Freedman Elizabeth⁷,Taylor Steve M.¹⁷^ORCID,Prudhomme-O’Meara Wendy¹⁷

Affiliation:

1. Duke Global Health Institute, Duke University, Durham, North Carolina, USA

2. School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya

3. Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya

4. Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, North Carolina, USA

5. Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA

6. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA

7. Division of Infectious Diseases, School of Medicine, Duke University, Durham, North Carolina, USA

Abstract

Plasmodium falciparum is the deadliest human malaria parasite, and infections consisting of concurrent, multiple strains are common in regions of high endemicity. During transitions within and between the parasite’s mosquito and human hosts, these strains are subject to population bottlenecks, and distinct parasite strains may have differential fitness in the various environments encountered.

Funder

National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

Triangle Center for Evolutionary Medicine

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02277-22

Reference40 articles.

1. Genotyping cognate Plasmodium falciparum in humans and mosquitoes to estimate onward transmission of asymptomatic infections