Immunologic Pathways in Protective versus Maladaptive Host Responses to Attenuated and Pathogenic Strains of Mycoplasma gallisepticum

Author:

Beaudet Jessica123,Tulman Edan R.12,Pflaum Katherine12,Canter Jessica A.12,Silbart Lawrence K.123,Geary Steven J.12

Affiliation:

1. Department of Pathobiology and Veterinary Sciences, University of Connecticut, Storrs, Connecticut, USA

2. Center of Excellence for Vaccine Research, University of Connecticut, Storrs, Connecticut, USA

3. Department of Allied Health Sciences, University of Connecticut, Storrs, Connecticut, USA

Abstract

Mycoplasmas are small bacterial commensals or pathogens that commonly colonize host mucosal tissues and avoid rapid clearance, in part by stimulating inflammatory, immunopathogenic responses. We previously characterized a wide array of transcriptomic perturbations in avian host tracheal mucosae infected with virulent, immunopathologic Mycoplasma gallisepticum ; however, mechanisms delineating these from protective responses, such as those induced upon vaccination, have not been thoroughly explored.

Funder

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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