Affiliation:
1. Department of Bacteriology and Public Health, School of Veterinary Medicine, Tuskegee Institute, Alabama
Abstract
Njoku-Obi, Augustine
N. (School of Veterinary Medicine, Tuskegee Institute, Ala.),
Edward M. Jenkins, Jessie C. Njoku-Obi, Joanne Adams, and Verdell Covington
. Production and nature of
Listeria monocytogenes
hemolysins. J. Bacteriol.
86:
1–8. 1963.—Hemolysin produced by various strains of
Listeria monocytogenes
varied in quality and quantity, depending on medium, incubation temperature and time, and biological variations in the organisms. The hemolysin was inactivated by filtration (through Seitz, Selas, or sintered-glass filters), heat, oxygen, and formalin. Sodium thiosulfate reactivated hemolysin inactivated by filtration and oxygen. The hemolysin was protein in nature, migrating electrophoretically as a gamma-globulin, and highly antigenic in the rabbit. Although no toxicity was observed in intact mice injected with hemolysin, a possible leukocytolysis was noted with isolated mice peritoneal exudate cells. Due to the high antihemolytic activity of normal sera from various species, the possible use of an antilisteriolysin test in serological diagnosis is questioned.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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