Gac Is a Transcriptional Repressor of the Lyme Disease Spirochete’s OspC Virulence-Associated Surface Protein-Reference-Cited by-同舟云学术

Gac Is a Transcriptional Repressor of the Lyme Disease Spirochete’s OspC Virulence-Associated Surface Protein

Published:2023-04-25 Issue:4 Volume:205 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Castro-Padovani Tatiana N.¹,Saylor Timothy C.¹,Husted Olivia T.¹,Krusenstjerna Andrew C.¹,Jusufovic Nerina¹,Stevenson Brian¹²^ORCID

Affiliation:

1. Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA

2. Department of Entomology, University of Kentucky College of Agriculture, Food, and Ecology, Lexington, Kentucky, USA

Abstract

Borrelia burgdorferi

sensu lato requires its surface-exposed OspC protein in order to establish infection in humans and other vertebrate hosts. Bacteria that either do not produce OspC during transmission or fail to repress OspC after infection is established are rapidly cleared by the host.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00440-22

Reference83 articles.

1. Outer-surface protein C of the Lyme disease spirochete: A protein induced in ticks for infection of mammals

2. Delineating the Requirement for the Borrelia burgdorferi Virulence Factor OspC in the Mammalian Host

3. Borrelia burgdorferi OspC Protein Required Exclusively in a Crucial Early Stage of Mammalian Infection

4. Rapid Clearance of Lyme Disease Spirochetes Lacking OspC from Skin

5. Lipoprotein succession in B orrelia burgdorferi : similar but distinct roles for OspC and VlsE at different stages of mammalian infection

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