Synchrotron-Based X-Ray Fluorescence Microscopy Reveals Accumulation of Polymyxins in Single Human Alveolar Epithelial Cells-Reference-Cited by-同舟云学术

Synchrotron-Based X-Ray Fluorescence Microscopy Reveals Accumulation of Polymyxins in Single Human Alveolar Epithelial Cells

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Azad Mohamad A. K.¹,Zhang Shuo²,Li Jiayao²,Kim Yeonuk²,Yu Heidi H.¹,Fulcher Alex J.³,Howard Daryl L.⁴,de Jonge Martin D.⁴,James Simon A.⁴,Roberts Kade D.¹,Velkov Tony⁵,Fu Jing²,Zhou Qi Tony⁶^ORCID,Li Jian¹^ORCID

Affiliation:

1. Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

2. Department of Mechanical and Aerospace Engineering, Monash University, Clayton, Victoria, Australia

3. Monash Micro Imaging, Monash University, Clayton, Victoria, Australia

4. Australian Synchrotron, Clayton, Victoria, Australia

5. Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia

6. Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA

Abstract

Intravenous administration of the last-line polymyxins results in poor drug exposure in the lungs and potential nephrotoxicity, whereas inhalation therapy offers better pharmacokinetics/pharmacodynamics for pulmonary infections by delivering the antibiotic directly to the infection site. However, polymyxin inhalation therapy has not been optimized, and adverse effects can occur.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02314-20

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