Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses

Author:

Wang Chenlong123,Kang Huiling124,Tan Ming56,Cong Jingyuan13,Su Dan4ORCID,Li Xuemei1,Chen Yutao1ORCID

Affiliation:

1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

2. School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China

3. University of Chinese Academy of Sciences, Beijing, China

4. State Key Laboratory of Biotherapy, West China Hospital, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China

5. Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

6. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

Abstract

Human noroviruses (huNoVs) are the most important viral pathogens causing epidemic acute gastroenteritis worldwide. Previous studies indicated that histo-blood group antigens (HBGAs) are critical host-susceptibility factors affecting huNoV host susceptibility, host range, and probably prevalence.

Funder

National Basic Research Program

Strategic Priority Research Program of the Chinese Academy of Sciences

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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