Inhibition of Toxoplasma gondii protein synthesis by azithromycin-Reference-Cited by-同舟云学术

Inhibition of Toxoplasma gondii protein synthesis by azithromycin

Published:1993-08 Issue:8 Volume:37 Page:1701-1703
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Blais J¹,Garneau V¹,Chamberland S¹

Affiliation:

1. Laboratoire et Service d'Infectiologie, Centre de Recherche du Centre Hospitalier, Université Laval, Québec, Canada.

Abstract

Azithromycin was shown to specifically inhibit the protein synthesis of Toxoplasma gondii in experimental systems by using free tachyzoites and T. gondii-infected mouse macrophages. RNA synthesis of the parasite was not affected by azithromycin. Inhibition of protein synthesis was also proportional to the relative anti-Toxoplasma activity of three macrolides.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.37.8.1701

Reference13 articles.

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2. Synthesis and in vitro and in vivo activity of novel 9-deoxo-9a-aza-9a-homoerythromycin A derivatives; a new class of macrolide antibiotics, the azalides;Bright G. M.;J. Antibiot.,1988

3. Use of mouse macrophage cell lines for in vitro propagation of Toaoplasma gondii RH tachyzoites;Chamberland S.;Proc. Soc. Exp. Biol. Med.,1991

4. Comparative activity of macrolides against Toxoplasma gondii demonstrating utility of an in vitro microassay;Chamberland S.;Antimicrob. Agents Chemother.,1991

5. Recognition of Toxoplasma gondii excreted and secreted antigens by human sera from acquired and congenital toxoplasmosis: identification of markers of acute and chronic infection;Decoster A.;Clin. Exp. Immunol.,1988

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