Distribution of Hydrophobic Residues Is Crucial for the Fusogenic Properties of the Ebola Virus GP2 Fusion Peptide-Reference-Cited by-同舟云学术

Distribution of Hydrophobic Residues Is Crucial for the Fusogenic Properties of the Ebola Virus GP2 Fusion Peptide

Published:2004-02-15 Issue:4 Volume:78 Page:2131-2136
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Adam B.¹,Lins L.¹,Stroobant V.²,Thomas A.¹,Brasseur R.¹

Affiliation:

1. Centre de Biophysique Moléculaire Numérique, FSAGX, 5030 Gembloux

2. Ludwig Institute, UCL, Leuven, Belgium

Abstract

ABSTRACT The lipid-destabilizing properties of the N-terminal domain of the GP2 of Ebola virus were investigated. Our results suggest that the domain of Ebola virus needed for fusion is shorter than that previously reported. The fusogenic properties of this domain are related to its oblique orientation at the lipid/water interface owing to an asymmetric distribution of the hydrophobic residues when helical.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.4.2131-2136.2004

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