A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques-Reference-Cited by-同舟云学术

A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques

Published:2021-03-10 Issue:7 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Matsuoka Saori¹,Kuwata Takeo²,Ishii Hiroshi¹,Sekizuka Tsuyoshi³,Kuroda Makoto³,Sano Masato¹,Okazaki Midori¹,Yamamoto Hiroyuki¹,Shimizu Mikiko²,Matsushita Shuzo²,Seki Yohei⁴,Saito Akatsuki⁴,Sakawaki Hiromi⁵,Hirsch Vanessa M.⁶^ORCID,Miura Tomoyuki⁵,Akari Hirofumi⁴⁵^ORCID,Matano Tetsuro¹²⁷^ORCID

Affiliation:

1. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan

2. Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

3. Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan

4. Primate Research Institute, Kyoto University, Inuyama, Japan

5. Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

6. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

7. The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Abstract

Vaccines against a wide variety of infectious diseases have been developed mostly to induce antibodies targeting pathogens. However, a small but significant percentage of people fail to mount potent antibody responses after vaccination, while the underlying mechanism of host failure in antibody induction remains largely unclear.

Funder

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02455-20

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