Activity of Novel Benzoxazinorifamycins against Rifamycin-Resistant Streptococcus pyogenes
Author:
Affiliation:
1. Novartis Institutes for Biomedical Research, Inc., Infectious Disease, Cambridge, MA 02139
2. ActivBiotics, Inc., 110 Hartwell Ave., Lexington, MA 02421
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Link
https://journals.asm.org/doi/pdf/10.1128/AAC.50.5.1908-1909.2006
Reference13 articles.
1. rpoB Mutations in Streptococcus mitis Clinical Isolates Resistant to Rifampin
2. Acocella, G. 1983. Pharmacokinetics and metabolism of rifampin in humans. Rev. Infect. Dis.5(Suppl. 3):S428-S432.
3. Characterization of Mutations in the rpoB Gene That Confer Rifampin Resistance in Staphylococcus aureus
4. rpoB Mutation Conferring Rifampin Resistance in Streptococcus pyogenes
5. Chen, J. Y., C. P. Fung, F. Y. Chang, L. Y. Huang, J. C. Chang, and L. K. Siu. 2004. Mutations of the rpoB gene in rifampicin-resistant Streptococcus pneumoniae in Taiwan. J. Antimicrob. Chemother.53:375-378.
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2. Structure-Based Design of Novel Benzoxazinorifamycins with Potent Binding Affinity to Wild-Type and Rifampin-Resistant MutantMycobacterium tuberculosisRNA Polymerases;Journal of Medicinal Chemistry;2012-04-05
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4. Rifalazil Retains Activity Against Rifampin-resistant Mutants of Chlamydia pneumoniae;The Journal of Antibiotics;2008-08
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