Vertical HIV-1 Transmission in the Setting of Maternal Broad and Potent Antibody Responses-Reference-Cited by-同舟云学术

Vertical HIV-1 Transmission in the Setting of Maternal Broad and Potent Antibody Responses

Published:2022-06-08 Issue:11 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tu Joshua J.¹,Kumar Amit¹²,Giorgi Elena E.³,Eudailey Joshua⁴,LaBranche Celia C.⁵^ORCID,Martinez David R.⁶,Fouda Genevieve G.¹⁷⁸^ORCID,Moreau Yvetane⁹,Thomas Allison⁹,Montefiori David¹⁵,Gao Feng¹⁰¹¹,Sagar Manish⁹^ORCID,Permar Sallie R.¹⁴^ORCID

Affiliation:

1. Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA

2. BioAgilytix Labs, Durham, North Carolina, USA

3. Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

4. Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA

5. Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA

6. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

7. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

8. Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

9. Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA

10. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA

11. School of Medicine, Jinan University, Guangzhou, Guangdong, People’s Republic of China

Abstract

As mother to child transmission (MTCT) of HIV plays a major part in the persistence of the HIV/AIDS epidemic and bnAb-based passive and active vaccines are a primary strategy for HIV prevention, research in this field is of great importance. While previous MTCT research has investigated the neutralizing antibody activity of HIV-infected women, this is, to our knowledge, the largest study identifying differences in bnAb specificity of maternal plasma between transmitting and nontransmitting women.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00231-22

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