<i>Pseudomonas aeruginosa</i> producing FIM-1-metallo-β-lactamase: emergence and cross-transmission in a long-term acute care rehabilitation hospital-Reference-Cited by-同舟云学术

Pseudomonas aeruginosa producing FIM-1-metallo-β-lactamase: emergence and cross-transmission in a long-term acute care rehabilitation hospital

Published:2024-07-09 Issue:7 Volume:68 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Antonelli Alberto¹²³^ORCID,Coppi Marco¹²³,Bonaiuto Chiara¹²,Giovacchini Nicla¹²,Grifoni Camilla³⁴,Vaggelli Guendalina²,Pupillo Roberto⁵,Vannetti Federica⁵,Farese Alberto⁶,Viaggi Bruno⁷,Pollini Simona¹²³,Rossolini Gian Maria¹²³^ORCID

Affiliation:

1. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

2. Microbiology and Virology Unit, Careggi University Hospital, Florence, Italy

3. NARR Joint Laboratory for Antimicrobial Resistance Research and Control, University of Florence-IRCCS Don Gnocchi Foundation, Florence, Italy

4. Severe Brain Injuries Unit, IRCCS Don Gnocchi Foundation, Florence, Italy

5. Medical Direction, IRCCS Don Gnocchi Foundation, Florence, Italy

6. Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy

7. Intensive Care Unit for Neurological Injuries, Careggi University Hospital, Florence, Italy

Abstract

ABSTRACT FIM-1 metallo-β-lactamase was previously detected in sporadic Pseudomonas aeruginosa clinical isolates. Here, we report on FIM-1-positive P. aeruginosa from two patients who had shared the same ward in a long-term acute care rehabilitation hospital. Whole-genome sequencing analysis revealed close relatedness of these isolates, which belonged to an ST235 sublineage (clade 8/14) different from those previously reported. Results highlighted the occurrence of clonal diversity among FIM-positive strains and the possibility of their cross-transmission in some healthcare settings.

Funder

Ministero dell'Università e della Ricerca

Ministero della Salute

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00574-24

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