Systematic Analysis of Mobile Genetic Elements Mediating β-Lactamase Gene Amplification in Noncarbapenemase-Producing Carbapenem-Resistant Enterobacterales Bloodstream Infections

Author:

Shropshire W. C.1ORCID,Konovalova A.2ORCID,McDaneld P.3,Gohel M.1,Strope B.1,Sahasrabhojane P.1,Tran C. N.1,Greenberg D.45ORCID,Kim J.6,Zhan X.6,Aitken S.7ORCID,Bhatti M.8ORCID,Savidge T. C.910,Treangen T. J.11ORCID,Hanson B. M.12ORCID,Arias C. A.13ORCID,Shelburne S. A.114ORCID

Affiliation:

1. Department of Infectious Diseases and Infection Control, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

2. Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA

3. Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

4. Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA

5. Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, USA

6. Department of Bioinformatics, UT Southwestern Medical Center, Dallas, Texas, USA

7. Division of Pharmacy, Michigan Medicine at University of Michigan, Ann Arbor, Michigan, USA

8. Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

9. Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA

10. Department of Pathology, Texas Children’s Hospital, Houston, Texas, USA

11. Department of Computer Science, Rice University, Houston, Texas, USA

12. Center for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, Texas, USA

13. Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA

14. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Abstract

Carbapenem-resistant Enterobacterales (CRE) are considered urgent antimicrobial resistance (AMR) threats. The vast majority of CRE research has focused on carbapenemase-producing Enterobacterales (CPE) even though noncarbapenemase-producing CRE (non-CP-CRE) comprise 50% or more of isolates in some surveillance studies.

Funder

National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Welch Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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