Affiliation:
1. Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
Abstract
Mammalian host defense against viral infection includes broad-acting cellular restriction factors, as well as effectors of intrinsic and innate immunity. IFI16 is a critical nuclear host defense factor and intrinsic immune protein involved in binding viral DNA genomes, thereby repressing the replication of nucleus-replicating viruses, including the human herpes simplex virus 1.
Funder
HHS | NIH | National Institute of General Medical Sciences
National Science Foundation
Edward Mallinckrodt, Jr. Foundation
Princeton Catalysis Initiative
Publisher
American Society for Microbiology
Subject
Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology
Cited by
10 articles.
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