Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro

Author:

Zhan Y1,Cheers C1

Affiliation:

1. Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.

Abstract

Marked differences in the abilities of living and heat-killed Brucella abortus and Listeria monocytogenes organisms to induce production of tumor necrosis factor alpha by in vitro-cultured macrophages were observed. Interleukin-1 and interleukin-6 appeared to be under different control. The results are discussed in relation to the induction of gamma interferon-producing Th1 cells and acquired cellular resistance to infection by living vaccines but not killed vaccines.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference24 articles.

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4. Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-~-stimulated macrophages by induction of tumor necrosis factor-~;Green S. J.;J. Immunol.,1990

5. Evidence that tumour necrosis factor has an important role in antibacterial resistance;Havell E. A.;J. Immunol.,1989

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