Vanadate-Resistant Mutants of Neurospora crassa Are Deficient in a High-Affinity Phosphate Transport System-Reference-Cited by-同舟云学术

Vanadate-Resistant Mutants of Neurospora crassa Are Deficient in a High-Affinity Phosphate Transport System

Published:1983-01 Issue:1 Volume:153 Page:292-296
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Bowman Barry J.¹,Allen Kenneth E.²,Slayman Carolyn W.²

Affiliation:

1. Department of Biology, Thimann Laboratories, University of California, Santa Cruz, California 95064

2. Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510

Abstract

Mutant strains of Neurospora crassa have been selected which grow on media containing vanadate, an inhibitor of the plasma membrane ATPase. The mutations all map to a single region (designated van ) on the left arm of linkage group VII. The van mutants are unable to take up vanadate from the medium and are also deficient in the uptake of phosphate via a derepressible, high-affinity phosphate transport system. In the van mutants, the K m for phosphate transport is elevated as much as 35-fold, indicating that the van locus may code for a structural component of the high-affinity phosphate transport system.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.153.1.292-296.1983

Reference8 articles.

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2. Vanadate uptake in Neurospora crassa occurs via phosphate transport system II;Bowman B. J.;J. Bacteriol.,1982

3. Genetic and microbiological research techniques for Neurospora crassa;Davis R. H.;Methods Enzymol.,1969

4. Kuroda H. J. Warncke D. Sanders U.-P. Hansen K. E. Allen ad B. J. Bowman. 1980. Effects of vanadate on the electrogenic proton pump in Neurospora p. 507-508. In R. M. Spanswick W. J. Lucas and J. Dainty (ed.) Plant membrane transport: current conceptual issues. Elsevier-North Holland Amsterdam.

5. Phosphate transport in Neurospora: derepression of a high-affinity transport system during phosphorus starvation;Lowendorf H. S.;Biochim. Biophys. Acta,1975

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