Reduction of CD8 T Cell Functionality but Not Inhibitory Capacity by Integrase Inhibitors-Reference-Cited by-同舟云学术

Reduction of CD8 T Cell Functionality but Not Inhibitory Capacity by Integrase Inhibitors

Published:2022-03-09 Issue:5 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Richter Enrico¹²,Bornemann Lea³,Korencak Marek¹²,Alter Galit⁴^ORCID,Schuster Marc³,Esser Stefan⁵⁶,Boesecke Christoph⁷,Rockstroh Juergen⁷,Gunzer Matthias³⁸,Streeck Hendrik¹²^ORCID

Affiliation:

1. Institute of Virology, University Hospital, University of Bonn, Bonn, Germany

2. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany

3. Institute for Experimental Immunology and Imaging, University Duisburg-Essen, Essen, Germany

4. Massachusetts General Hospital, Boston, Massachusetts, USA

5. HPSTD HIV Clinic, University Hospital, University Duisburg-Essen, Essen, Germany

6. Institute for Translational HIV Research, University Hospital Essen, University Duisburg-Essen, Essen, Germany

7. Department of Medicine I, University Hospital Bonn, University of Bonn, Bonn, Germany

8. Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany

Abstract

Integrase Strand Transfer Inhibitors (INSTI) are recommended by national and international guidelines as a key component of ART in the treatment of HIV-infected patients. In particular, their efficacy, tolerability and low drug-drug interaction profile have made them to the preferred choice as part of the first-line regimen in treatment-naive individuals.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01730-21

Reference54 articles.

1. Kill

2. CD8 T-Cell Proliferative Capacity Is Compromised in Primary HIV-1 Infection

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5. HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue

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1. SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells;Nature Communications;2022-08-19

2. Integrase Inhibitors Partially Restore Bacterial Translocation, Inflammation and Gut Permeability Induced by HIV Infection: Impact on Gut Microbiota;Infectious Diseases and Therapy;2022-05-26