Deletion of cox7c Results in Pan-Azole Resistance in Aspergillus fumigatus

Abstract

In Aspergillus fumigatus , the most prevalent resistance to azoles results from mutational modifications of the azole target protein Cyp51A, but there are non- cyp51A mutants resistant to azoles, and the mechanisms underlying the resistance of these strains remain to be explored. Here, we identified a novel cytochrome c oxidase, cox7c (W56*), nonsense mutation in the laboratory and found that it caused reduced colony growth and resistance to multiantifungal agents.