A Population Pharmacokinetics and Pharmacodynamic Approach To Optimize Tazobactam Activity in Critically Ill Patients-Reference-Cited by-同舟云学术

A Population Pharmacokinetics and Pharmacodynamic Approach To Optimize Tazobactam Activity in Critically Ill Patients

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kalaria Shamir N.¹²^ORCID,Gopalakrishnan Mathangi¹,Heil Emily L.²³

Affiliation:

1. University of Maryland School of Pharmacy, Center for Translational Medicine, Baltimore, Maryland, USA

2. University of Maryland Medical Center, Department of Pharmacy Services, Baltimore, Maryland, USA

3. University of Maryland School of Pharmacy, Department of Pharmacy Practice and Science, Baltimore, Maryland, USA

Abstract

The percentage of the time that the free drug concentration remains above a concentration threshold (% fT > concentration threshold) has frequently been identified to be the optimal pharmacokinetic (PK)-pharmacodynamic (PD) target of interest for tazobactam using in vitro infection models.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02093-19

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