Mutagenic Effect of Temperature-Sensitive Mutants of Gene 42 (dCMP Hydroxymethylase) of Bacteriophage T4

Author:

Chiu Che-Shen1,Greenberg G. Robert1

Affiliation:

1. Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48104

Abstract

Certain temperature-sensitive mutants of gene 42 of bacteriophage T4 increase the reversion rates of some rII mutants in the same genome by about 4 to 10 times. This effect was usually found at 34 C, an intermediate permissive temperature, but not at 28 C.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference8 articles.

1. Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4;Bernstein H.;J. Virol.,1971

2. Evidence for a possible direct role of dCMP hydroxymethylase in T4 phage DNA synthesis;Chiu C. S.;Cold Spring Harbor Symp. Quant. Biol.,1968

3. The structural gene for deoxyribonucleic acid polymerase in bacteriophages T4 and T5;DeWaard A.;Proc. Nat. Acad. Sci. U.S.A.,1965

4. Antimutagenic DNA polymerases of bacteriophage T4;Drake J. W.;Cold Spring Harbor Symp. Quant. Biol.,1968

5. Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4;Muzyczka N.;J. Biol. Chem.,1972

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