Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides-Reference-Cited by-同舟云学术

Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Khabibullina Nelli F.¹,Tereshchenkov Andrey G.²,Komarova Ekaterina S.³⁴,Syroegin Egor A.¹,Shiriaev Dmitrii I.²,Paleskava Alena⁵⁶,Kartsev Victor G.⁷,Bogdanov Alexey A.²,Konevega Andrey L.⁵⁶⁸,Dontsova Olga A.²⁴⁹,Sergiev Petr V.²⁴,Osterman Ilya A.²⁴,Polikanov Yury S.¹¹⁰¹¹^ORCID

Affiliation:

1. Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA

2. Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia

3. Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia

4. Skolkovo Institute of Science and Technology, Skolkovo, Russia

5. Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, Gatchina, Russia

6. Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, Russia

7. Interbioscreen, Ltd., Chernogolovka, Russia

8. NRC Kurchatov Institute, Moscow, Russia

9. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

10. Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, USA

11. Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, Illinois, USA

Abstract

Although macrolides are known as excellent antibacterials, their medical use has been significantly limited due to the spread of bacterial drug resistance. Therefore, it is necessary to develop new potent macrolides to combat the emergence of drug-resistant pathogens.

Funder

Illinois State Startup Fund

Moscow University Development Program

HHS | National Institutes of Health

Russian Foundation for Basic Research

Russian Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02266-18