Population Pharmacokinetic Modeling of Bedaquiline among Multidrug-Resistant Pulmonary Tuberculosis Patients from China

Author:

Zou Jin1,Chen Shuyan23,Rao Weiqiao4,Fu Liang5ORCID,Zhang Jiancong1,Liao Yunli4,Zhang Ying1,Lv Ning1,Deng Guofang5,Yang Shijin1,Lin Liang4,Li Lujin6,Liu Siqi4,Qu Jiuxin1

Affiliation:

1. Department of Clinical Laboratory, Shenzhen Third People’s Hospital, Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, China

2. College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China

3. Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, China

4. BGI-Shenzhen, Shenzhen, China

5. Division Two of Pulmonary Diseases Department, Shenzhen Third People’s Hospital, Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, China

6. Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Abstract

Bedaquiline has been widely used as a part of combination dosage regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB) patients with limited options. Although the effectiveness and safety of bedaquiline have been demonstrated in clinical trials, limited studies have investigated the significant pharmacokinetics and the impact of genotype on bedaquiline disposition.

Funder

GDSTC | Science and Technology Planning Project of Guangdong Province

GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province

Science and Technology Foundation of Shenzhen City

The third people's hospital of Shenzhen

CCDC | State Key Laboratory of Infectious Disease Prevention and Control

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3