Reconstitution of Bam Complex-Mediated Assembly of a Trimeric Porin into Proteoliposomes

Author:

Hussain Sunyia1,Peterson Janine H.1,Bernstein Harris D.1ORCID

Affiliation:

1. Genetics and Biochemistry Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Porins are a widespread family of homotrimers that represent a substantial fraction of the total protein located in the OM of many proteobacteria. These proteins facilitate the nonspecific diffusion of small molecules across the outer membrane and strongly influence the susceptibility of bacteria to clinically used antibiotics.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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